Caspase-1 rabbit pAb

Cat :A11625

Caspase-1,Caspase1,Caspase 1,A11625, 11625, CASP1 IL1BC IL1BCE,

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

IF,WB,IHC,ELISA
Reactivity

Human,Rat
Dilution

IF: 1:50-200 WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000
Storage

-20°C/1 year
Specificity

Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400
Uniprot No

P29466
Alternative names

caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

caspase 1(CASP1) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],
Other

CASP1 IL1BC IL1BCE, Caspase-1
Mol.Wt (Da)

45159
Concentration

1 mg/ml