CD146 mouse mAb(PT0278)

Cat :A11887

CD146 ,,A11887, 11887, MCAM MUC18, CD146, Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Mouse
Applications

IHC,WB
Reactivity

Human
Dilution

IHC 1:100-300，WB 1:500-2000
Storage

-20°C/1 year
Specificity

This antibody detects endogenous levels of human CD146
Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Immunogen

Synthesized peptide derived from human CD146
Uniprot No

P43121
Alternative names

Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Monoclonal
Isotype

IgG
Background

function:Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.,similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.,
Other

MCAM MUC18, CD146
Concentration

1 mg/ml