COL4A3 rabbit pAb

Cat :A12828

COL4A,A12828, 12828, COL4A3, Collagen alpha-3(IV) chain, COL4A3; Collagen alpha-3(IV) chain; Goodpasture antigen

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

IHC,IF,ELISA
Reactivity

Human
Dilution

IHC: 1:100 - 1:300. IF: 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

COL4A3 Polyclonal Antibody detects endogenous levels of COL4A3 protein.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen IV alpha3. AA range:801-850
Uniprot No

Q01955
Alternative names

COL4A3; Collagen alpha-3(IV) chain; Goodpasture antigen
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

collagen type IV alpha 3 chain(COL4A3) Homo sapiens Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal r
Other

COL4A3, Collagen alpha-3(IV) chain
Mol.Wt (Da)

161813
Concentration

1 mg/ml