Cortactin (phospho Tyr421) rabbit pAb

Cat :A12908

Cortactin,A12908, 12908, CTTN, Src substrate cortactin, CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

WB,IHC,ELISA
Reactivity

Human,Mouse,Rat
Dilution

WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:20000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

Phospho-Cortactin (Y421) Polyclonal Antibody detects endogenous levels of Cortactin protein only when phosphorylated at Y421.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human Cortactin around the phosphorylation site of Tyr421. AA range:388-437
Uniprot No

Q14247
Alternative names

CTTN; EMS1; Src substrate cortactin; Amplaxin; Oncogene EMS1
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

cortactin(CTTN) Homo sapiens This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010],
Other

CTTN, Src substrate cortactin
Mol.Wt (Da)

61636
Concentration

1 mg/ml