CYFIP2 rabbit pAb

Cat :A13266

Price： ¥900¥1600

Size： 50ul 100ul

Source

Rabbit
Applications

WB,ELISA
Reactivity

Human,Mouse,Rat
Dilution

WB 1:500-2000, ELISA 1:10000-20000
Storage

-20°C/1 year
Specificity

CYFIP2 Polyclonal Antibody detects endogenous levels of CYFIP2
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

Synthesized peptide derived from CYFIP2 at AA range: 1171-1220
Uniprot No

Q96F07
Alternative names

Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,
Other

CYFIP2, CYFIP2
Mol.Wt (Da)

148399
Concentration

1 mg/ml