ERCC1 mouse mAb(1B10)

Cat :A14192

ERCC,A14192, 14192, ERCC1, DNA excision repair protein ERCC-1, ERCC1; DNA excision repair protein ERCC-1

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Mouse
Applications

WB,IHC,
Reactivity

Human
Dilution

IHC: 100-300.WB: 1:1000
Storage

-20°C/1 year
Specificity

The antibody detects endogenous ERCC1 proteins.
Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Immunogen

Synthetic Peptide of ERCC1
Uniprot No

P07992
Alternative names

ERCC1; DNA excision repair protein ERCC-1
Form

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Clonality

Monoclonal
Isotype

IgG
Background

ERCC excision repair 1, endonuclease non-catalytic subunit(ERCC1) Homo sapiens The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein ge
Other

ERCC1, DNA excision repair protein ERCC-1
Mol.Wt (Da)

32562
Concentration

1 mg/ml