HUS1 rabbit pAb

Cat :A15981

Price： ¥900¥1600

Size： 50ul 100ul

Source

Rabbit
Applications

WB,ELISA
Reactivity

Human
Dilution

WB 1:500-2000 ELISA 1:5000-20000
Storage

-20°C/1 year
Specificity

HUS1 Polyclonal Antibody detects endogenous levels of protein.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

Synthesized peptide derived from human protein . at AA range: 160-240
Uniprot No

O60921
Form

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

HUS1 checkpoint clamp component(HUS1) Homo sapiens The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011],
Other

HUS1, Checkpoint protein HUS1 (hHUS1)
Concentration

1 mg/ml