MARCH1 rabbit pAb

Cat :A17322

MARCH,A17322, 17322, MARCH1, E3 ubiquitin-protein ligase MARCH1, MARCH1; RNF171; E3 ubiquitin-protein ligase MARCH1; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; MARCH-I; RING finger protein 171

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

IHC,WB,ELISA
Reactivity

Human
Dilution

WB 1:500-2000 IHC: 1:100 - 1:300. ELISA: 1:40000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

MARCH1 Polyclonal Antibody detects endogenous levels of 40603 protein.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

Synthesized peptide derived from the Internal region of human 40603.
Uniprot No

Q8TCQ1
Alternative names

MARCH1; RNF171; E3 ubiquitin-protein ligase MARCH1; Membrane-associated RING finger protein 1; Membrane-associated RING-CH protein I; MARCH-I; RING finger protein 171
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

membrane associated ring-CH-type finger 1(MARCH1) Homo sapiens MARCH1 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH1 downregulates the surface expression of major histocompatibility complex (MHC) class II molecules (see MIM 142880) and other glycoproteins by directing them to the late endosomal/lysosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Thibodeau et al., 2008 [PubMed 18389477]; De Gassart et al., 2008 [PubMed 18305173]).[supplied by OMIM, Mar 2010],
Other

MARCH1, E3 ubiquitin-protein ligase MARCH1
Mol.Wt (Da)

32308
Concentration

1 mg/ml