MeCP2 rabbit pAb

Cat :A17456

MeCP,A17456, 17456, MECP2, Methyl-CpG-binding protein 2, Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

WB
Reactivity

Human
Dilution

WB: 1:2000
Storage

-20°C/1 year
Specificity

The antibody detects endogenous MeCP2 proteins.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Immunogen

Synthetic Peptide of MeCP2
Uniprot No

P51608
Alternative names

Methyl-CpG-binding protein 2 (MeCp-2 protein) (MeCp2)
Form

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
Clonality

Polyclonal
Isotype

IgG
Background

methyl-CpG binding protein 2(MECP2) Homo sapiens DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isofor
Other

MECP2, Methyl-CpG-binding protein 2
Concentration

1 mg/ml