MLKL (phospho S358) rabbit pAb

Cat :A17657

Price： ¥900¥1600

Size： 50ul 100ul

Source

Rabbit
Applications

IHC,WB
Reactivity

Human, Mouse, Rat
Dilution

IHC 1:50-200, WB 1:500-2000
Storage

-20°C/1 year
Specificity

This antibody detects endogenous phospho levels of MLKL (phospho S358) at Human, Mouse, Rat
Source/Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Immunogen

Synthesized peptide derived from human MLKL (phospho S358)
Uniprot No

Q8NB16
Alternative names

Mixed lineage kinase domain-like protein
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

mixed lineage kinase domain like(MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
Other

MLKL, MLKL (phospho S358)
Concentration

1 mg/ml