ORC1 rabbit pAb

Cat :A19159

ORC1 ,A19159, 19159, ORC1, Origin recognition complex subunit 1, ORC1; ORC1L; PARC1; Origin recognition complex subunit 1; Replication control protein 1

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

WB,ELISA
Reactivity

Human
Dilution

WB: 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

ORC1 Polyclonal Antibody detects endogenous levels of ORC1 protein.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human ORC1L. AA range:331-380
Uniprot No

Q13415
Alternative names

ORC1; ORC1L; PARC1; Origin recognition complex subunit 1; Replication control protein 1
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

origin recognition complex subunit 1(ORC1) Homo sapiens The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcr
Other

ORC1, Origin recognition complex subunit 1
Mol.Wt (Da)

97350
Concentration

1 mg/ml