PAK4 (phospho Ser474) rabbit pAb

Cat :A19424

PAK,A19424, 19424, PAK4, Serine/threonine-protein kinase PAK 4, PAK4; KIAA1142; Serine/threonine-protein kinase PAK 4; p21-activated kinase 4; PAK-4

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

WB,IHC,ELISA
Reactivity

Human,Mouse,Rat
Dilution

WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:20000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

Phospho-PAK4 (S474) Polyclonal Antibody detects endogenous levels of PAK4 protein only when phosphorylated at S474.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human PAK4/5/6 around the phosphorylation site of Ser474. AA range:441-490
Uniprot No

O96013
Alternative names

PAK4; KIAA1142; Serine/threonine-protein kinase PAK 4; p21-activated kinase 4; PAK-4
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

p21 (RAC1) activated kinase 4(PAK4) Homo sapiens PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Other

PAK4, Serine/threonine-protein kinase PAK 4
Mol.Wt (Da)

64072
Concentration

1 mg/ml