PEN2 rabbit pAb

Cat :A19686

Price： ¥900¥1600

Size： 50ul 100ul

Source

Rabbit
Applications

IHC
Reactivity

Human, Mouse,Rat
Dilution

IHC 1：50-200
Storage

-20°C/1 year
Specificity

This antibody detects endogenous levels of PEN2 at Human/Mouse/Rat
Source/Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Immunogen

Synthesized peptide derived from human PEN2
Uniprot No

Q9NZ42
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
Other

PSENEN PEN2 MDS033, PEN2
Mol.Wt (Da)

11110
Concentration

1 mg/ml