phospho-MLKL (S358) mouse mAb(6B4)

Cat :A19785

Price： ¥900¥1600

Size： 50ul 100ul

Source

Mouse
Applications

IHC
Reactivity

Human
Dilution

WB: 1:500 - 1:2000.IHC:1:50-200. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

phospho-MLKL (S358) protein detects endogenous levels of MLKL
Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Immunogen

Synthetic Peptide of phospho-MLKL (S358)
Uniprot No

Q8NB16
Alternative names

MLKL
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Monoclonal
Isotype

IgG
Background

mixed lineage kinase domain like(MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
Other

MLKL, MLKL
Concentration

1 mg/ml