PTEN mouse mAb(2C10)

Cat :A20319

Price： ¥900¥1600

Size： 50ul 100ul

Source

Mouse
Applications

IHC
Reactivity

Human
Dilution

IHC 1:100-200
Storage

-20°C/1 year
Specificity

PTEN protein detects endogenous levels of PTEN
Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Immunogen

Synthetic Peptide of PTEN at AA range of 320-400
Uniprot No

P60484
Alternative names

PTEN
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Monoclonal
Isotype

IgG
Background

phosphatase and tensin homolog(PTEN) Homo sapiens This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate ener
Other

PTEN, PTEN
Concentration

1 mg/ml