Rb (phospho Ser249) rabbit pAb

Cat :A20603

Price： ¥900¥1600

Size： 50ul 100ul

Source

Rabbit
Applications

IF,ELISA
Reactivity

Human,Mouse,Rat
Dilution

IF: 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

Phospho-Rb (S249) Polyclonal Antibody detects endogenous levels of Rb protein only when phosphorylated at S249.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Ser249. AA range:221-270
Uniprot No

P06400
Alternative names

RB1; Retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

RB transcriptional corepressor 1(RB1) Homo sapiens The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008],
Other

RB1, Retinoblastoma-associated protein
Mol.Wt (Da)

106159
Concentration

1 mg/ml