Sgo1 (phospho Ser14) rabbit pAb

Cat :A21460

Sgo,A21460, 21460, SGOL1, Shugoshin-like 1, SGOL1; SGO1; Shugoshin-like 1; hSgo1; Serologically defined breast cancer antigen NY-BR-85

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

IHC,ELISA
Reactivity

Human
Dilution

IHC: 1:100 - 1:300. ELISA: 1:5000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

Phospho-Sgo1 (S14) Polyclonal Antibody detects endogenous levels of Sgo1 protein only when phosphorylated at S14.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human SGO1 around the phosphorylation site of Ser14. AA range:1-50
Uniprot No

Q5FBB7
Alternative names

SGOL1; SGO1; Shugoshin-like 1; hSgo1; Serologically defined breast cancer antigen NY-BR-85
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

shugoshin 1(SGO1) Homo sapiens The protein encoded by this gene is a member of the shugoshin family of proteins. This protein is thought to protect centromeric cohesin from cleavage during mitotic prophase by preventing phosphorylation of a cohesin subunit. Reduced expression of this gene leads to the premature loss of centromeric cohesion, mis-segregation of sister chromatids, and mitotic arrest. Evidence suggests that this protein also protects a small subset of cohesin found along the length of the chromosome arms during mitotic prophase. An isoform lacking exon 6 has been shown to play a role in the cohesion of centrioles (PMID: 16582621 and PMID:18331714). Mutations in this gene have been associated with Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, characterized by the co-occurrence of Sick Sinus Syndrome (SSS) and Chronic Intestinal Pseudo-obstruction (CIPO) within the first four decades of life (PMID:25282101). Fibro
Other

SGOL1, Shugoshin-like 1
Mol.Wt (Da)

64190
Concentration

1 mg/ml