TACE (phospho Thr735) rabbit pAb

Cat :A22240

TACE,A22240, 22240, ADAM17, CSVP; TACE; Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

IF,ELISA
Reactivity

Human,Mouse,Rat
Dilution

IF: 1:200 - 1:1000. ELISA: 1:5000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

TACE Polyclonal Antibody detects endogenous levels of TACE protein.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human ADAM 17. AA range:701-750
Uniprot No

P78536
Alternative names

ADAM17; CSVP; TACE; Disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD antigen CD156b
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

ADAM metallopeptidase domain 17(ADAM17) Homo sapiens This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation o
Other

ADAM17, Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme; CD antigen CD156b
Mol.Wt (Da)

93021
Concentration

1 mg/ml