Topo IIα (phospho Thr1343) rabbit pAb

Cat :A22751

Topo,A22751, 22751, TOP2A, DNA topoisomerase 2-alpha, TOP2; DNA topoisomerase II; alpha isozyme

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

WB,ELISA
Reactivity

Human
Dilution

WB: 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

Phospho-Topo IIα (T1343) Polyclonal Antibody detects endogenous levels of Topo IIα protein only when phosphorylated at T1343.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human TOP2A around the phosphorylation site of Thr1343. AA range:1311-1360
Uniprot No

P11388
Alternative names

TOP2A; TOP2; DNA topoisomerase 2-alpha; DNA topoisomerase II; alpha isozyme
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

topoisomerase (DNA) II alpha(TOP2A) Homo sapiens This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also pla
Other

TOP2A, DNA topoisomerase 2-alpha
Mol.Wt (Da)

174385
Concentration

1 mg/ml