ZAP-70 (phospho Tyr315) rabbit pAb

Cat :A23563

ZAP,A23563, 23563, ZAP70, Tyrosine-protein kinase ZAP-70, SRK;

Price： ¥900¥1600

Size： 50ul 100ul

Datasheet

MSDS

Source

Rabbit
Applications

WB,IHC,ELISA
Reactivity

Human,Mouse
Dilution

WB: 1:500 - 1:2000. IHC: 1:100 - 1:300. ELISA: 1:10000. Not yet tested in other applications.
Storage

-20°C/1 year
Specificity

Phospho-ZAP-70 (Y315) Polyclonal Antibody detects endogenous levels of ZAP-70 protein only when phosphorylated at Y315.
Source/Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Immunogen

The antiserum was produced against synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr315. AA range:281-330
Uniprot No

P43403
Alternative names

ZAP70; SRK; Tyrosine-protein kinase ZAP-70; 70 kDa zeta-chain associated protein; Syk-related tyrosine kinase
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Polyclonal
Isotype

IgG
Background

zeta chain of T cell receptor associated protein kinase 70(ZAP70) Homo sapiens This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Other

ZAP70, Tyrosine-protein kinase ZAP-70
Mol.Wt (Da)

69872
Concentration

1 mg/ml