Bax mouse mAb(6F11)

Cat :A23921

Price： ¥900¥1600

Size： 50ul 100ul

Source

Mouse
Applications

IF,WB,IHC
Reactivity

Human,Rat,Mouse,Chicken
Dilution

IF: 1:50-200 WB 1:1000-2000, IHC 1:100-200
Storage

-20°C/1 year
Specificity

Bax protein detects endogenous levels of BAX
Source/Purification

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Immunogen

Synthetic Peptide of Bax at AA range of 30-110
Uniprot No

Q07812
Form

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Clonality

Monoclonal
Isotype

IgG
Background

The protein encoded by BAX (BCL2 associated X, apoptosis regulator) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for BAX.
Concentration

1 mg/ml