Duloxetine HCl

Cat :A50014

Price： ¥2700

Size： 10mg

Targets

Proteasome
Storage

3 years -20℃ Powder; 6 months -80℃ in solvent (DMSO, water, etc.)
Solubility

Dissolved in DMSO, and diluted in PBS
Description

MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM.
In vitro

Administration of MG-132 effectively rescues the expression levels and plasma membrane localization of dystrophin, β-dystroglycan, α-bdystroglycan, and α-sarcoglycan in skeletal muscle fibers from mdx mice, reduces muscle membrane damage, and ameliorates the histopathological signs of muscular dystrophy. MG-132 treatment significantly reduces immobilization-induced skeletal muscle atrophy in mice, by downregulating the muscle-specific ubiquitin ligases atrogin-1/MAFbx and MuRF-1 mRNA.
Mol.Wt

475.62
formula

C26H41N3O5